Water → Furo[2,3-c]pyridin-5-ylmethanol

HRID 15330Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 15330
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.O.[OH-].[Na+]>O1CCOCC1>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22047292HCID 22047292, Verbindung

Produkt 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanolAusbeute 70,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Also to yield the desired compound: Furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g, 6 mmol) was dissolved in 1,4-dioxane (30 ml) and water (10 ml) and treated with 2N sodium hydroxide solution (12 ml) and stirred at RT for 18 h. The mixture was then partitioned between ethyl acetate and water, the organic layer was dried and evaporated to dryness to provide the desired compound (0.63 g).

Aufarbeitung

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customthe organic layer was dried
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-adde202e72824f69a5298fe6bf9019ec
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732461B2

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