Hydrochloric Acid → Methyl (1,2-benzoxazol-3-yl)acetate

HRID 1533013Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1533013
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]COCC.Cl>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 3017292-(1,2-Benzoxazol-3-yl)acetic acid

Produkt 1

HCID 2763403Methyl (1,2-benzoxazol-3-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1,2-benzisoxazole-3-acetic acid (prepared according to G. Casini et al, J. Het. Chem. 6, 1969, 279) (18 g), ether saturated with dry HCl (150 ml) and methanol (200 ml) was stirred for 2 h at room temperature. Removal of the volatiles in vacuo gave methyl 1 ,2-benzisoxazole-3-acetate (17 g) as an oil. The oil was dissolved in tetrahydrofuran (100 ml) and added dropwise to a suspension of lithium aluminium hydride (6 g) in tetrahydrofuran (200 ml) at 0-10° C. followed by stirring for 30 min at 15° C. Usual work-up gave 2-(1 ,2-benzisoxazol-3-yl)ethanol (13 g) as an oil.

Aufarbeitung

  1. customRemoval of the volatiles in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d617c80cd00c42ca844004d2d4805f0a
Quelldatensatz
uspto-grants-2001_03
Patentnummer
US06207677B1

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