Methyl Thioglycolate → 6-Methoxy-benzo[B]thiophene-2-carboxylic acid methyl ester

Reaktionsgleichung

F[C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[H-].[Na+].[SH:14][CH2:15][C:16]([O:18][CH3:19])=[O:17]>>[CH3:19][O:18][C:16]([C:15]1[S:14][C:2]2[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=2[CH:4]=1)=[O:17]

Komponenten

Edukt 3

HCID 16907Methyl Thioglycolate

HCID 24758Sodium hydride

HCID 27348732-Fluoro-4-methoxybenzaldehyde

Produkt 1

HCID 534861116-Methoxy-benzo[B]thiophene-2-carboxylic acid methyl ester

Versuchsvorschrift

Using 2.5 g (16.2 mmol) of 2-fluoro-4-methoxybenzaldehyde, 0.97 g (24.3 mmol) of sodium hydride (60% pure) and 1.89 g (17.8 mmol) of methyl mercaptoacetate, 3.05 g (84.7% of theory) of the title compound are obtained.

Quellen und Nachweise

ORD-Eintrag: ord-743a5e0c9015488eb101d423a762ba83
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07732477B2

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