Potassium Carbonate → HCID 67202658, Verbindung

HRID 15550

Reaktionsgleichung

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]Br.C([O-])([O-])=O.[K+].[K+].[C:19]([O:23][C:24](=[O:49])[CH2:25][N:26]1[C:30]2[CH:31]=[CH:32][C:33]([NH:35][S:36]([C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)(=[O:38])=[O:37])=[CH:34][C:29]=2[N:28]=[C:27]1[CH2:46][CH2:47][CH3:48])([CH3:22])([CH3:21])[CH3:20]>CC#N.CCOC(C)=O.O>[C:19]([O:23][C:24](=[O:49])[CH2:25][N:26]1[C:30]2[CH:31]=[CH:32][C:33]([N:35]([CH2:5][C:4]3[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=3[C:2]([F:12])([F:11])[F:1])[S:36]([C:39]3[CH:40]=[CH:41][C:42]([F:45])=[CH:43][CH:44]=3)(=[O:37])=[O:38])=[CH:34][C:29]=2[N:28]=[C:27]1[CH2:46][CH2:47][CH3:48])([CH3:22])([CH3:21])[CH3:20]

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

2-Trifluoromethylbenzyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

Aufarbeitung

filtrationfiltered through an Extrelut column
washThe column was washed with EtOAc
concentrationthe filtrate was concentrated
customThe crude product was carried onto the next reaction without any further purification or characterization

Quellen und Nachweise

ORD-Eintrag: ord-e2aa916a4ef6425894be5da718f4b2c1
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07732618B2

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