Ammonia → Oseltamivir

HRID 15606

Reaktionsgleichung

Reaktionsgleichung von HRID 15606
[CH3:1][CH2:2][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:4][CH3:5].OP(O)(O)=O.O.N>C(Cl)Cl>[CH3:5][CH2:4][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:2][CH3:1]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 78000Tamiflu

Produkt 1

HCID 65028OseltamivirAusbeute 108,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Oseltamivir phosphate (20 gm, HPLC purity: 97%) is stirred with water (100 ml) and methylene chloride (100 ml) for 10 minutes at 25-30° C. and then pH of the mass is adjusted to 9-10 with liquor ammonia. Separated the layers, the organic layer is subjected to carbon treatment and filtered on hiflo bed. Washed the hiflo bed with methylene chloride (20 ml) and then distilled the organic layer under vacuum at 40° C. to give 16.5 gm of oseltamivir free base as a residue.

Aufarbeitung

  1. customSeparated the layers
  2. filtrationfiltered on hiflo bed
  3. washWashed the hiflo bed with methylene chloride (20 ml)
  4. distillationdistilled the organic layer under vacuum at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-950cdd41c55d4453b1774526ef2cfe7b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732632B2

Verknüpfte Notizen

Wird geladen…