Hydrazine hydrate (1:1) → 6-Phenyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

HRID 15723Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 15723
[C:1]([O:5][C:6]([N:8]1[CH2:13][C:12](=[CH:14]O)[C:11](=O)[CH2:10][CH:9]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:24][NH2:25]>CO>[C:1]([O:5][C:6]([N:8]1[CH:9]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][C:11]2[NH:24][N:25]=[CH:14][C:12]=2[CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 685032875-Hydroxymethylene-4-oxo-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 593424006-Phenyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Compound 51 (310 mg, 1.02 mmol) from the previous step was dissolved in MeOH (3 ml). Hydrazine monohydrate (0.1 ml, 2.04 mmol) was added to the solution and then stirred at room temperature for 1 hour. Solvent was removed under reduced pressure to afford a yellow gel as the desired product. LCMS 300.2 (M+1)

Aufarbeitung

  1. customSolvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5cb7788b0c2a435e9b5881cb3ca4164c
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732609B2

Notizen zur Reaktion

Wird geladen…