Reaktionsgleichung
ClC1C=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[CH2:11][CH2:10][N:9]2[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])=[CH:4]C=1.FC1C=CC([Mg]Br)=CC=1.O.[NH2:35]N.[NH:37]1[CH2:42]CC(=O)CC1>>[CH:5]([CH:8]1[N:9]([C:15]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:16])[CH2:10][C:11]2[CH:42]=[N:37][NH:35][C:12]=2[CH2:13]1)([CH3:4])[CH3:6]Komponenten
5
Versuchsvorschrift
5-(4-Chlorophenylsulfonyl)-6-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-Benzyl 2-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate, prepared as described for compound 67 in Example using 4-fluorophenylmagnesium bromide, was formylated and treated with hydrazine hydrate as described for compound 50 in Example 1 to give benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate. This compound was then deprotected and treated with 4-chlorophenylsulfonyl chloride followed by NaOH as described for compound 52 in Example 1.
Quellen und Nachweise
- ORD-Eintrag
- ord-ba3ee268dc61420d8103506a34f40fc0
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07732609B2
Verknüpfte Notizen
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