p-Toluenesulfonic acid → 6-Acetoxy-2-naphthyl-alpha-methylacetic acid

HRID 1576476Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1576476
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2.[C:17](OC(=O)C)(=[O:19])[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[C:17]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:6]=[CH:5]2)(=[O:19])[CH3:18]

Komponenten

4

Edukt 3

HCID 6101p-Toluenesulfonic acidHCID 7918Acetic AnhydrideHCID 162920Desmethylnaproxen

Produkt 1

HCID 203351926-Acetoxy-2-naphthyl-alpha-methylacetic acid

Versuchsvorschrift

A mixture of 2.2 g. of 6-hydroxy-2-naphthyl-α-methylacetic acid, 50 ml. of acetic anhydride, and 100 mg. of p-toluenesulfonic acid is stirred for four hours at 50°C. The mixture is evaporated, water is added, and the mixture is extracted with diethyl ether which is washed with water to neutrality, dried over sodium sulfate, and evaporated to yield 6-acetoxy-2-naphthyl-α-methylacetic acid.

Aufarbeitung

  1. additionA mixture of 2.2 g
  2. customThe mixture is evaporated
  3. additionwater is added
  4. extractionthe mixture is extracted with diethyl ether which
  5. washis washed with water to neutrality
  6. dry with materialdried over sodium sulfate
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-27ee9e02a6f94e1b8638044b0b648da4
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03980699

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