Pyrazole → cis-4,6-Diethyl-5-(pyridin-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

HRID 15766

Reaktionsgleichung

Reaktionsgleichung von HRID 15766
[CH2:1]([CH:3]1[CH2:8][C:7](=O)[CH2:6][CH:5]([CH2:10][CH3:11])[N:4]1[S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)(=[O:14])=[O:13])[CH3:2].C([C@H]1N[C@@H](CC)CC2(OCCO2)C1)C.Cl.N1C=CC=CC=1S(Cl)(=O)=O.CN(C(OC)OC)C.[NH:54]1[CH:58]=CC=[N:55]1.O.NN>>[CH2:1]([C@H:3]1[C:8]2[CH:58]=[N:54][NH:55][C:7]=2[CH2:6][C@@H:5]([CH2:10][CH3:11])[N:4]1[S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)(=[O:14])=[O:13])[CH3:2]

Komponenten

7

Edukt 6

HCID 1048PyrazoleHCID 24654Hydrazine hydrate (1:1)HCID 78373Dimethylformamide dimethyl acetalHCID 13791306Pyridine-2-sulfonyl chloride hydrochlorideHCID 59342374cis-7,9-Diethyl-1,4-dioxa-8-azaspiro[4.5]decaneHCID 68501382HCID 68501382, Verbindung

Produkt 1

HCID 68495820cis-4,6-Diethyl-5-(pyridin-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Versuchsvorschrift

Prepared by treatment of 2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using pyridine-2-sulfonyl chloride hydrochloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15,

Quellen und Nachweise

ORD-Eintrag
ord-d6e25c829d9240aa83bcc02a7ca1062c
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732609B2

Verknüpfte Notizen

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