Methanesulfonyl chloride → HCID 21511645, Verbindung
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[O:6][CH2:7][CH:8]([OH:11])[CH2:9][OH:10].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[OH:11][CH:8]([CH2:7][O:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)[CH2:9][O:10][S:13]([CH3:12])(=[O:15])=[O:14]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
This example illustrates steps 3 and 4 of the generic process, of the invention, and further illustrates the preparation of the compounds of formula II of the invention. In this example 50 grams of 3-(thiazol-2-oxy)-1,2-propanediol is dissolved in 200 ml. of pyridine at 20°C and then 22.5 ml. of methylsulfonyl chloride is added. The mixture is allowed to stand for 10 minutes and then separated into two portions (1/10 portion and one 9/10 portion). The 1/10 portion is diluted with water, then filtered and the resulting filter cake dried affording 2-hydroxy-1-methylsulfonyloxy-3-(thiazol-2-oxy)-propane.