Acetic Acid → HCID 86734028, Verbindung

HRID 1576780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1576780
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:37])(=[O:36])[CH3:35]>C(O)C>[C:34]([OH:37])(=[O:36])[CH3:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 86734023HCID 86734023, Verbindung

Produkt 1

HCID 86734028HCID 86734028, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (116 mg., 0.25 mmole) in ethanol (2 ml.) was treated with 0.1N aqueous acetic acid (2.5 ml. 0.25 mmole) and the resulting solution was evaporated under vacuum. The residue was treated with water (ca 1 ml.) and the undissolved solid (66 mg.) was removed by filtration. The filtrate was diluted to 5 ml. with distilled water, thereby giving a 1% aqueous solution of the title compound.

Aufarbeitung

  1. customthe resulting solution was evaporated under vacuum
  2. additionThe residue was treated with water (ca 1 ml.)
  3. customthe undissolved solid (66 mg.) was removed by filtration
  4. additionThe filtrate was diluted to 5 ml

Quellen und Nachweise

ORD-Eintrag
ord-899a9718125a4c7b83e44bf443dcac5c
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03983111

Notizen zur Reaktion

Wird geladen…