Citric Acid → HCID 86734022, Verbindung

HRID 1576786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1576786
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37]>C(O)C>[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

Komponenten

4

Edukt 2

HCID 311Citric AcidHCID 86734023HCID 86734023, Verbindung

Produkt 1

HCID 86734022HCID 86734022, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (0.93 g.) in ethanol (1 ml.) was treated with a 0.1 M solution of citric acid (20 ml.) at room temperature. The solution was evaporated to dryness and redissolved in distilled water (5 ml.). The resulting solution was filtered and the collected residue was washed with water (1 ml.). The filtrate and washings were made up to 9.2 ml with distilled water thereby giving a solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione citrate at concentration 100 mg./ml. with respect to steroid (pH 3.5).

Aufarbeitung

  1. customThe solution was evaporated to dryness
  2. dissolutionredissolved in distilled water (5 ml.)
  3. filtrationThe resulting solution was filtered
  4. washthe collected residue was washed with water (1 ml.)

Quellen und Nachweise

ORD-Eintrag
ord-eb21d54d283449a59487cd40719d516f
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03983111

Notizen zur Reaktion

Wird geladen…