Acetone → 1-(4-chlorophenyl)-2-phenoxyethanone

HRID 1577023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1577023
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].CC(C)=O>O>[O:18]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 996PhenolHCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromide

Produkt 1

HCID 14715261-(4-chlorophenyl)-2-phenoxyethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 23.3 g. (0.1 mol.) of α-bromo-p-chloroacetophenone, 10.0 g. (0.1 mol.) of phenol and 14.5 g. (0.1 mol.) of potassium carbonate in 65 ml. of dry acetone is refluxed for 12 hours. The reaction mixture is cooled, poured into 500 ml. of water and the precipitate formed is collected by filtration and recrystallized from ethanol to give α-phenoxy-p-chloroacetophenone.

Aufarbeitung

  1. additionA mixture of 23.3 g
  2. temperatureThe reaction mixture is cooled
  3. additionpoured into 500 ml
  4. filtrationis collected by filtration
  5. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a2befa0a7b754456bbec798a739346d1
Quelldatensatz
uspto-grants-1976_09
Patentnummer
US03983245

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