Thionyl Chloride → 4-(Pyrid-4-yl)butyroyl chloride hydrochloride

HRID 1577847Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1577847
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClC(Cl)C.CN(C)C=O>[ClH:16].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([Cl:1])=[O:13])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 467359454-Pyridin-4-YL-butyric acid hydrochloride

Produkt 1

HCID 205699404-(Pyrid-4-yl)butyroyl chloride hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 63651,1-DichloroethaneLösungsmittel

Versuchsvorschrift

4-(Pyrid-4-yl)butyric acid hydrochloride (ca. 35 g) in dichloroethane (250 ml) and dimethylformamide (0.5 ml) was treated with thionyl chloride (100 ml). The vigorous exothermic reaction was allowed to subside and then the mixture was heated under reflux for 10 minutes, followed by evaporation to dryness in vacuo to give crude 4-(pyrid-4-yl)butyroyl chloride hydrochloride.

Aufarbeitung

  1. customThe vigorous exothermic reaction
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 10 minutes
  4. customfollowed by evaporation to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a207383eb217417cae2155479e9acfab
Quelldatensatz
uspto-grants-1981_09
Patentnummer
US04289772

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