Hydrochloric Acid → HCID 178505637, Verbindung

HRID 1578526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1578526
[OH-].[K+].[CH:3]([NH:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])=[S:8])=O.Cl>O>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:9]1[CH:3]=[N:5][N:6]=[C:7]1[SH:8]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

Produkt 1

HCID 178505637HCID 178505637, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

One and one-tenth grams (20 mmoles) of potassium hydroxide were dissolved in 50 ml. of water. 1-Formyl-4-(2-fluorophenyl)thiosemicarbazide, 3.5 g. (16.5 mmoles), was dissolved in the basic solution by warming on the steam bath until solution was completed. The heating was continued for one hour. The cooled reaction mixture was poured into a dilute solution of hydrochloric acid. The insoluble product was recovered from the acidic solution by filtration. The product was washed with water, collected and dried. The yield was 2.5 g. of 4-(2-fluorophenyl)-1,2,4-triazole-3-thiol, m.p. about 166°-167°C.

Aufarbeitung

  1. dissolution(16.5 mmoles), was dissolved in the basic solution
  2. temperatureby warming on the steam bath until solution
  3. customThe cooled reaction mixture
  4. filtrationThe insoluble product was recovered from the acidic solution by filtration
  5. washThe product was washed with water
  6. customcollected
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-16a0bf1041d64cea8a7aee23d4da0988
Quelldatensatz
uspto-grants-1976_02
Patentnummer
US03937713

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