Triethylamine → 3-(4-Methoxyphenyl)cyclobutan-1-one

HRID 1578802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1578802
Cl[C:2]1[C:3](=[O:14])[CH2:4][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.C(N(CC)CC)C>[Pd].CO>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][C:6]([CH:5]2[CH2:4][C:3](=[O:14])[CH2:2]2)=[CH:11][CH:10]=1

Komponenten

5

Edukt 2

HCID 8471TriethylamineHCID 214251912-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one

Produkt 1

HCID 114466413-(4-Methoxyphenyl)cyclobutan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one (17.4 g., 0.084 mole), triethylamine (11.7 ml., 0.084 mole), and 2.1 g. of 10% Pd/C in 300 ml. of 10% aqueous methanol is shaken under H2 (50 psi) until reduction is complete (30 min). The mixture is filtered and the filtrate evaporated. An ether solution of the residue is washed (water), dried (MgSO4), and evaporated to give 15.4 g. of an oil which is chromatographed on alumina using benzene.

Aufarbeitung

  1. custom(30 min)
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. washAn ether solution of the residue is washed (water)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give 15.4 g
  8. customof an oil which is chromatographed on alumina

Quellen und Nachweise

ORD-Eintrag
ord-71cca5fb87c54723ba72c4103f608580
Quelldatensatz
uspto-grants-1976_02
Patentnummer
US03939196

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