Potassium Permanganate → HCID 12898485, Verbindung

HRID 1579392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1579392
[CH3:1][CH:2]([CH3:20])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)[OH:4].[Mn]([O-])(=O)(=O)=O.[K+]>CC(C)=O>[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)(=[O:4])[CH:2]([CH3:20])[CH3:1]

Komponenten

4

Edukt 2

HCID 516875Potassium PermanganateHCID 13207925HCID 13207925, Verbindung

Produkt 1

HCID 12898485HCID 12898485, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 2.7 g of 2-methyl-1-(5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-1-propanol, 60 ml of acetone and 1.5 g of potassium permanganate is refluxed for 6 hours. The reaction mixture is filtered, and the residue is washed thoroughly was chloroform. The filtrate and washings are concentrated, and the residue is purified by column chromatography on silica gel with chloroform as eluent, and further by recrystallization from ethanol to give 7-isobutyryl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine melting at 155°-156°C.

Aufarbeitung

  1. temperatureis refluxed for 6 hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed thoroughly was chloroform
  4. concentrationThe filtrate and washings are concentrated
  5. customthe residue is purified by column chromatography on silica gel with chloroform as eluent
  6. customfurther by recrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a725107989af4e2292a9931ddceeaf04
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03931199

Notizen zur Reaktion

Wird geladen…