1,3-Dibromopropane → 10-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

HRID 1579527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1579527
[NH2:1][C:2]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([OH:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:19][CH2:20][CH2:21]Br>C(O)(C)C>[C:12]1([C:10]2([OH:11])[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]3[CH2:19][CH2:20][CH2:21][N:1]=[C:2]23)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 80011,3-DibromopropaneHCID 215687052-amino-3-phenyl-3H-indol-3-ol

Produkt 1

HCID 1507593810-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2-Amino-3-phenyl-3H-indol-3-ol (2.24 g) was heated under reflux with isopropanol (20 ml) and 1,3-dibromopropane (2.0 g) for 20 hours. The reaction mixture was evaporated to 10 ml and diluted with a little ether. The title compound was obtained as its hydrobromide salt 0.73 g., m.p. 260°-262°C (decomp.) and could be recrystallized from methanol, ethanol or isopropanol with or without the addition of ethyl acetate or ether.

Aufarbeitung

  1. customThe reaction mixture was evaporated to 10 ml
  2. additiondiluted with a little ether

Quellen und Nachweise

ORD-Eintrag
ord-4d5a026f279c4f2688f8270abe7bd5c8
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03931226

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