Acetic Anhydride → HCID 21568996, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([CH3:15])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([CH3:15])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)(=[O:18])[CH3:17]Komponenten
3
Versuchsvorschrift
A mixture of 5.0 g (0.0248 mole) of methyl 5-(p-aminophenyl)-2-furyl ketone and 75 ml of acetic anhydride was heated at 70°-90° for 2 hours. The excess acetic anhydride was removed on a Calab evaporator, and the residual solid was recrystallized from ethyl acetate to yield 4.4 g (73%) of methyl 5-(p-acetamidophenyl)-2-furyl ketone. An analytical sample was prepared by drying a sample in the vacuum pistol at the temperature of refluxing chloroform, m.p. 214°-215°.
Aufarbeitung
- temperaturewas heated at 70°-90° for 2 hours
- customThe excess acetic anhydride was removed on a Calab evaporator
- customthe residual solid was recrystallized from ethyl acetate