Benzene → Ethyl 5-methyl-2-phenylimidazole-4-acetate

HRID 1580096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1580096
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([OH:16])=[O:15].[CH2:17](O)[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Komponenten

6

Edukt 4

HCID 241BenzeneHCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 215650655-Methyl-2-phenylimidazole-4-acetic acid

Produkt 1

HCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

About 40 g of 5-methyl-2-phenylimidazole-4-acetic acid, 100 ml of absolute ethanol, 1 g of p-toluenesulfonic acid and 650 ml of benzene is heated under reflux with azeotropic removal of water overnight (about 15 hours). The reaction mixture is filtered, washed with sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent evaporated in vacuo to yield the product, ethyl 5-methyl-2-phenylimidazole-4-acetate.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. washwashed with sodium bicarbonate solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-704dcf766cc24e3e82f991e7e055e8d0
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03932445

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