3-Amino-1-propanol → 1-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

HRID 1580631

Reaktionsgleichung

Reaktionsgleichung von HRID 1580631
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[OH:12][CH2:13][CH2:14][CH2:15][NH2:16]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:16][CH2:15][CH2:14][CH2:13][OH:12])=[S:11]

Komponenten

4

Edukt 2

HCID 90863-Amino-1-propanolHCID 1423861-Isothiocyanato-2,4-dimethylbenzene

Produkt 1

HCID 21711911-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

A solution of 2,4-dimethylphenylisothiocyanate in about 70 ml. of benzene was added dropwise to an agitated solution of 3-hydroxypropylamine (3.8 grams) in about 80 ml. of benzene. The resulting reaction mixture was maintained, with stirring, at ambient temperatures for about 16 hours. Following such period, the benzene in the reaction mixture was removed in vacuo and the residual oil triturated with ethyl ether and the desired product crystallized therefrom and washed again with ethyl ether. As a result of such operations, the desired N-(2,4-dimethylphenyl)-N'-(3-hydroxypropyl)-thiourea product was obtained as a white solid having a melting point of 90° - 93°C.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. temperaturewas maintained
  3. waitFollowing such period
  4. customthe benzene in the reaction mixture was removed in vacuo
  5. customthe residual oil triturated with ethyl ether
  6. customthe desired product crystallized
  7. washwashed again with ethyl ether
  8. customAs a result of such operations

Quellen und Nachweise

ORD-Eintrag
ord-94561180df864c719153891f18af9760
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03933833

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