Tetrahydrofuran → HCID 11118078, Verbindung

HRID 1581649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1581649
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[C:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:5][CH:4]=1.O1CCCC1>[Pd].C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:7][CH:8]=1

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 2331125-(4-Methoxybenzylidene)-thiazolidine-2,4-dione

Produkt 1

HCID 11118078HCID 11118078, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

5-[(4-Methoxyphenyl)methylidene]thiazolidine-2,4-dione (6.00 g, 25.5 mmol), 10% palladium on carbon (6.00 g) and a mixed solvent of tetrahydrofuran and ethanol (2:1 v/v, 300 mL) were mixed, and hydrogenation was performed at room temperature and at an initial pressure of 294 kPa. After completion of the reaction, catalyst was filtered and the filtrate was concentrated. The residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v) to obtain 5.84 g (97%) of the title compound as colorless powder.

Aufarbeitung

  1. customwas performed at room temperature
  2. customAfter completion of the reaction, catalyst
  3. filtrationwas filtered
  4. concentrationthe filtrate was concentrated
  5. customThe residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v)

Quellen und Nachweise

ORD-Eintrag
ord-5061c0be22b4472e954f66723d78019f
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06730687B1

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