BISOPROLOL FUMARATE → Bisoprolol

HRID 1581900Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1581900
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:3].C(/C(O)=O)=C\C(O)=O>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:1]

Komponenten

3

Edukt 1

HCID 6917733BISOPROLOL FUMARATE

Produkt 1

HCID 2405Bisoprolol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of bisoprolol was prepared as follows. To 529.2 g of purified water were added 180 g of bisoprolol fumarate 2:1. The mixture was stirred for 10 minutes to dissolve the drug. 10.8 g of talc USP (Whitaker, Clark and Daniels Inc., South Plainfield, N.J., USA) were added to the solution and the mixture was stirred for 20 minutes.

Aufarbeitung

  1. dissolutionto dissolve the drug
  2. stirringthe mixture was stirred for 20 minutes

Quellen und Nachweise

ORD-Eintrag
ord-481f489f89154a1d87d9b2d300813349
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06733789B1

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