HCID 20260583, Verbindung → 6-(Thiophen-3-yl)hexan-1-ol

HRID 1583430Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583430
[S:1]1[CH:5]=[CH:4][C:3]([C:6]#[C:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[CH:2]1>C(O)C.[Pd]>[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[CH:2]1

Komponenten

4

Edukt 1

HCID 20260583HCID 20260583, Verbindung

Produkt 1

HCID 135575466-(Thiophen-3-yl)hexan-1-olAusbeute 80,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Thiophenehexanol was prepared by reduction of 8.4 g of 6-(3-thiophenyl)-5-hexyn-1-ol, in 100 ml of ethanol over 1.0 g of 10% palladium/carbon at atmospheric pressure. After 8 hours a second catalyst loading was added and the reduction continued over night. The residue obtained after filtration and evaporation of the solvent was evaporatively distilled to give 6.9 g (80%) of 3-thiophenehexanol, bp 135°-147° C./0.2 mm.

Aufarbeitung

  1. additionAfter 8 hours a second catalyst loading was added
  2. waitthe reduction continued over night
  3. customThe residue obtained
  4. filtrationafter filtration and evaporation of the solvent
  5. distillationwas evaporatively distilled

Quellen und Nachweise

ORD-Eintrag
ord-112c6df4316543c49c4ddb14d4638aa9
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04551460

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