[N+:1]([O-:4])([OH:3])=[O:2].C(OC(=O)C)(=O)C.O[C@@H:13]1[CH2:17][C:16](=[O:18])[C:15]([CH2:19][CH:20]=[CH2:21])=[C:14]1[CH3:22]>C(Cl)(Cl)Cl>[CH3:22][C:14]1[C@H:13]([O:2][N+:1]([O-:4])=[O:3])[CH2:17][C:16](=[O:18])[C:15]=1[CH2:19][CH:20]=[CH2:21]Into a mixed solution of 5.5 g of fuming nitric acid and 22 g of acetic anhydride, kept at a temperature of -5° to 10° C., was added dropwise 4 g of (R)-4-hydroxy-3-methyl-2-(2-propenyl)-2-cyclopenten-1-one ([α]D25 : -14.9° (C=1.19, in chloroform), (R)-isomer/(S)-isomer=99.2/0.8). Thereafter, with the same operations as in Example 1, 5.02 g of crude (R)-3-methyl-4-nitroxy-2-(2-propenyl)-2-cyclopenten-1-one was obtained.
Wird geladen…
