Water → HCID 13535661, Verbindung

HRID 1583590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583590
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Cl)=[CH:7][CH:6]=1.[Cl:13][C:14]1[CH:25]=[CH:24][C:17]([O:18][C:19]([CH3:23])([CH3:22])[CH2:20][OH:21])=[CH:16][CH:15]=1.[OH-].[Na+].O>[Br-].C([N+](CC)(CC)CC1C=CC=CC=1)C.C1(C)C=CC=CC=1>[Cl:13][C:14]1[CH:25]=[CH:24][C:17]([O:18][C:19]([CH3:22])([CH3:23])[CH2:20][O:21][CH2:9][C:8]2[CH:11]=[CH:12][C:5]([O:4][CH2:3][CH2:2][F:1])=[CH:6][CH:7]=2)=[CH:16][CH:15]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 191086602-(4-Chlorophenoxy)-2-methylpropan-1-olHCID 202592671-(Chloromethyl)-4-(2-fluoroethoxy)benzene

Produkt 1

HCID 13535661HCID 13535661, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 165294Benzyltriethylammonium bromideKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture consisting of 1.0 g of 4-(2-fluoroethoxy)benzyl chloride, 1.0 g of 2-(4-chlorophenoxy)-2-methylpropyl alcohol, 0.3 g of triethylbenzylammonium bromide and 20 g of a 50% aqueous solution of sodium hydroxide was stirred at 50° C. for 2 hours. The reaction mixture was cooled to room temperature, and poured into water. Toluene was added, and the mixture was fully stirred. The toluene layer was separated, washed with water, and dried over anhydrous sodium sulfate. Toluene and low-volatile components were evaporated under reduced pressure to give 1.6 g of the desired 4-(2-fluoroethoxy)benzyl 2-(4-chlorophenoxy)-2-methylpropyl ether.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature
  2. stirringthe mixture was fully stirred
  3. customThe toluene layer was separated
  4. washwashed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customToluene and low-volatile components were evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9eefc2268fd841b5bb7506413bc17f9e
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04552894

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