Glutaric anhydride → 4-Carboxybutyrylalanyl-alanyl Proline Ethylamide
Reaktionsgleichung
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH2:9]([NH:11][C:12](=[O:28])[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18](=[O:27])[C@H:19]([CH3:26])[NH:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH3:10]>CN(C)C=O>[CH2:9]([NH:11][C:12](=[O:28])[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18](=[O:27])[C@H:19]([CH3:26])[NH:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH:23][C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH3:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
1.7 g of glutaric anhydride was added to a solution of 4.0 grams of alanyl-alanyl proline ethylamide in 25 ml of dimethylformamide and the reaction solution heated for 1 hour at 60 degrees C. Then, the solution was evaporated and the resultant non-crystalline evaporation residue dissolved in 30 ml of ethyl acetate. After 48 hours of standing at 3 degrees C., 3.6 g of separated product was filtered off with a melting point of 154 to 156 degrees C. ([α]D20 -137.3 degrees (c 0.3; 50% methyl alcohol).