Dichromate ion → N-[N2-(1(S)-carboxy-3-phenylpropyl)-N6-carbamoylmethyl-L-lysyl]-L-proline

HRID 1583934

Reaktionsgleichung

Reaktionsgleichung von HRID 1583934
[C:1]([C@@H:4]([NH:13][C@H:14]([C:20]([N:22]1[CH2:29][CH2:28][CH2:27][C@H:23]1[C:24]([OH:26])=[O:25])=[O:21])[CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([OH:3])=[O:2].[C:30]([NH2:34])(=[O:33])[CH:31]=O.C(N)(=O)CO.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O>[Pd]>[C:1]([C@@H:4]([NH:13][C@H:14]([C:20]([N:22]1[CH2:29][CH2:28][CH2:27][C@H:23]1[C:24]([OH:26])=[O:25])=[O:21])[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:31][C:30](=[O:33])[NH2:34])[CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)([OH:3])=[O:2]

Komponenten

6

Edukt 4

HCID 24503Dichromate ionHCID 69021GlycolamideHCID 5362119LisinoprilHCID 117080452-oxoacetamide

Produkt 1

HCID 86740515N-[N2-(1(S)-carboxy-3-phenylpropyl)-N6-carbamoylmethyl-L-lysyl]-L-proline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

In the manner described above in Example 1, N-[N2 (1(S)-carboxy-3-phenylpropyl)-L-lysyl]-L-proline and glyoxylic acid amide (which can be prepared by the oxidation of glycolamide with pyridinum dichromate) were hydrogenated in the presence of 10% Pd on carbon catalyst to yield N-[N2 -(1(S)-carboxy-3-phenylpropyl)-N6 -carbamoylmethyl-L-lysyl]-L-proline.

Quellen und Nachweise

ORD-Eintrag
ord-1358a9d2be3f4fc4960233821e9749b9
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04555503

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