Water → HCID 21220308, Verbindung

HRID 1584816Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1584816
[Br:1][C:2]1[C:20]([F:21])=[CH:19][C:5]([C:6]([C:8](=[CH:14][NH:15][CH:16]2[CH2:18][CH2:17]2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4](F)[C:3]=1[CH3:23].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:23])=[C:4]2[C:5]([C:6](=[O:7])[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:14][N:15]2[CH:16]2[CH2:18][CH2:17]2)=[CH:19][C:20]=1[F:21]

Komponenten

5

Edukt 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 178471861HCID 178471861, Verbindung

Produkt 1

HCID 21220308HCID 21220308, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

In 175 ml of dimethyl sulfoxide was dissolved 35.0 g of ethyl 2-(4-bromo-2,5-difluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate, and 27.4 g of potassium carbonate was added to the solution, after which the resulting mixture was stirred at 100° C. for 30 minutes. The reaction mixture was cooled to room temperature, and 1,000 ml of water was then added thereto, after which the crystals formed were collected by filtration, to obtain 30.0 g of colorless, crystalline ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate.

Aufarbeitung

  1. additionwas added to the solution
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customafter which the crystals formed
  4. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ff799f89d2c648c1a90fc65a51119b63
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05935952

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