Water → (E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(pyrid-2-yl)sulfonyl]acrylonitrile

HRID 1585102Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585102
[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[C:11]=1[OH:12])[CH:7]=O)([CH3:3])[CH3:2].[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([CH2:25][C:26]#[N:27])(=[O:24])=[O:23].O>N1CCCCC1.C(O)C>[CH:1]([C:4]1[CH:5]=[C:6](/[CH:7]=[C:25](/[S:22]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)(=[O:24])=[O:23])\[C:26]#[N:27])[CH:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[C:11]=1[OH:12])([CH3:3])[CH3:2]

Komponenten

6

Edukt 3

HCID 962WaterHCID 827124-Hydroxy-3,5-bis(isopropyl)benzaldehydeHCID 5193552-Pyridinesulfonylacetonitrile

Produkt 1

HCID 10177190(E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(pyrid-2-yl)sulfonyl]acrylonitrileAusbeute 43,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8082PiperidineKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The reaction mixture of 450.0 mg of 3,5-diisopropyl-4-hydroxylbenzaldehyde, 400.0 mg of 2-pyridinesulphonylacetonitrile and a few drops of piperidine in 10.0 mL of ethanol was refluxed for 3 h and then cooled to room temperature. To the above reaction mixture was added 5.0 mL of water until crystallization began. After standing at 0° C. for 2 h, the solid was filtered, washed with cold water and dried in oven at 40° C. overnight to provide 350.0 mg of the titled compound.

Aufarbeitung

  1. temperaturewas refluxed for 3 h
  2. customuntil crystallization
  3. filtrationthe solid was filtered
  4. washwashed with cold water
  5. customdried in oven at 40° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-fa75939d82d84ee09132e3e934ec858b
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05935993

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