beta-D-Galactopyranose → 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose

HRID 1585190

Reaktionsgleichung

OC([C@@]1(O[C@@H]([C@@H]([C@@H](CO)O)O)[C@H](NC(C)=O)[C@@H](O)C1)[O:5][CH2:6][C@H:7]1[O:24][C@@H:11]([O:12][C@@H:13]2[C@@H:19]([CH2:20][OH:21])[O:18][CH:16]([OH:17])[C@H:15]([NH2:22])[C@H:14]2[OH:23])[C@H:10]([OH:25])[C@@H:9]([OH:26])[C@H:8]1[OH:27])=O.C(O)[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O.CC(N[C@H]1C([C@H](O)[C@H](O)CO)O[C@](OP(OC[C@H]2O[C@@H](N3C(=O)N=C(N)C=C3)[C@H](O)[C@@H]2O)([O-])=O)(C(O)=O)C[C@@H]1O)=O.[Na+]>>[O:12]([C@@H:13]1[C@@H:19]([CH2:20][OH:21])[O:18][CH:16]([OH:17])[C@H:15]([NH2:22])[C@H:14]1[OH:23])[C@@H:11]1[O:24][C@H:7]([CH2:6][OH:5])[C@H:8]([OH:27])[C@H:9]([OH:26])[C@H:10]1[OH:25]

Komponenten

Edukt 3

HCID 439353beta-D-Galactopyranose

HCID 23679065CMP-NeuAc

HCID 101111154GlyTouCan:G69038JL

Produkt 1

HCID 114732932-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose

Versuchsvorschrift

Synthesis of NeuAcα2-6Galβ1-4GlcNH2 βSEt. Galβ1-4GlcNH2 βSEt is prepared as described above and used directly or after isolation as acceptor for a β-D-galactoside α2-6-sialyltransferase (e.g. EC 2.4.99.1) reaction with a suitable glycosyl donor such as CMP-NeuAc.

Quellen und Nachweise

ORD-Eintrag: ord-b413794cfbe74c46bc90d63903c8c0d2
Quelldatensatz: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05936075

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