tert-Butanol → 86023-87-2

HRID 1585533Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585533
Br[C@H:2]1[C:28](=[O:29])[C@@:27]2([CH3:30])[C@@H:13]([CH2:14][C@@H:15]3[O:20][C@@:19]4([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]4)[C@@H:17]([CH3:18])[C@@H:16]32)[C@H:12]2[C@H:3]1[C@:4]1([CH3:32])[C@@H:9]([CH2:10][CH2:11]2)[CH2:8][C@@H:7]([OH:31])[CH2:6][CH2:5]1.C([OH:37])(C)(C)C.[OH-].[Na+]>O>[CH3:18][C@@H:17]1[C@:19]2([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]2)[O:20][C@H:15]2[CH2:14][C@@H:13]3[C@@:27]([CH3:30])([C@@H:16]12)[C@H:28]([OH:29])[C:2](=[O:37])[C@H:3]1[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C@:4]1([CH3:32])[CH2:5][CH2:6][C@H:7]([OH:31])[CH2:8]2

Komponenten

5

Edukt 3

HCID 6386tert-ButanolHCID 14798Sodium HydroxideHCID 10673254HCID 10673254, Verbindung

Produkt 1

HCID 15891086023-87-2

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
83 °C

Versuchsvorschrift

A glass lined reactor was charged with 12.4 Kg of (3β,5α,11β,25R)-11-bromospirostan-3-ol-12-one (24.34 mole), 33 gallons of t-butanol, 33 gallons of water and 7.5 Kg (189 mole, 7.75 eq) of sodium hydroxide pellets. The reaction was heated to reflux over 1.5 hours, maintained at -reflux for 4.5 hours (pot temperature was 83° C.), then cooled to room temperature. TLC at this point indicated complete reaction.

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureto reflux over 1.5 hours
  3. temperaturecooled to room temperature
  4. customreaction

Quellen und Nachweise

ORD-Eintrag
ord-ba9629a5c78d4b599847c0508d30ec4f
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05939398

Notizen zur Reaktion

Wird geladen…