StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Potassium Iodide → HCID 15346372, Verbindung

HRID 1585808
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1585808
[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[C:15]([OH:17])[C:14]([Cl:18])=[CH:13][C:12]=2[F:19])[N:4]=[C:5]2[C:10]=1[CH2:9][CH2:8][CH2:7][CH2:6]2.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Br[CH2:29][C:30]#[N:31]>C(C(CC)=O)C>[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[C:15]([O:17][CH2:29][C:30]#[N:31])[C:14]([Cl:18])=[CH:13][C:12]=2[F:19])[N:4]=[C:5]2[C:10]=1[CH2:9][CH2:8][CH2:7][CH2:6]2
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 1850782-Chloro-5-(3-chloro-4,5,6,7-tetrahydroindazol-2-yl)-4-fluorophenol

Produkt 1

HCID 15346372HCID 15346372, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7288
Ethyl ketone
Lösungsmittel
3×

Versuchsvorschrift

4.52 g of 3-chloro-2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydroindazole in 10 ml of diethyl ketone were added dropwise at approximately 20° C. to a suspension of 2.07 g of potassium carbonate and 2.49 g of potassium iodide in 150 ml of diethyl ketone. The reaction mixture was subsequently treated with 1.86 g of bromoacetonitrile in 10 ml of diethyl ketone. After the mixture had been refluxed for 10 hours, it was cooled, and the solvent was then removed. The residue was taken up in water, whereupon the solids formed were removed, washed with water and finally dried under reduced pressure at approximately 20° C. Yield: 3.20 g

Aufarbeitung

  1. temperatureAfter the mixture had been refluxed for 10 hours
  2. temperatureit was cooled
  3. customthe solvent was then removed
  4. customformed
  5. customwere removed
  6. washwashed with water
  7. customfinally dried under reduced pressure at approximately 20° C

Quellen und Nachweise

ORD-Eintrag
ord-4acb4efebf8c41b49dbb59c2d4183ae8
Quelldatensatz
uspto-grants-1999_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05939558

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion