Ammonia → 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine

HRID 1586396

Reaktionsgleichung

Reaktionsgleichung von HRID 1586396
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12](O)[N:11]=[C:10]([CH3:15])[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:18])=O.N>O>[Cl:18][C:12]1[CH:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[N:9]=[C:10]([CH3:15])[N:11]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 24813Phosphorus oxychlorideHCID 178418772HCID 178418772, Verbindung

Produkt 1

HCID 158701424-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 21 g of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine was added 63 ml of phosphorus oxychloride and the mixture was refluxed for 1 hour. This reaction mixture was cooled, poured into iced water, and neutralized with 28% aqueous ammonia and the crystals that separated out were collected by filtration. The crystals were washed with water and dried to provide 21 g of the title compound.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 1 hour
  2. temperatureThis reaction mixture was cooled
  3. customthe crystals that separated out
  4. filtrationwere collected by filtration
  5. washThe crystals were washed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5e7721a5343d4046bc84d39da4c7a344
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05945426

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