Hydrochloric Acid → (2S)-piperazine-2-carboxylic acid dihydrochloride

HRID 1586536Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1586536
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([O:9]C(C)(C)C)=[O:8].[ClH:14]>O>[ClH:14].[ClH:14].[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 45115680HCID 45115680, Verbindung

Produkt 1

HCID 2734260(2S)-piperazine-2-carboxylic acid dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

The crude tert-butyl (S)-piperazine-2-carboxylate from Example 7 was stirred in 2.9 g of water and 2.1 g (18.4 mmol) of 32 percent hydrochloric acid for 20 minutes at 100° C. The mixture was cooled to 0° C. and stirred for a further 1 hour. The hydrochloride which had precipitated out was filtered off and washed with 10 ml of dichloromethane. The yield of the title compound was 0.24 g (41 percent, based on tert-butyl pyrazinecarboxylate). The ee value was 77.6 percent.

Aufarbeitung

  1. customThe hydrochloride which had precipitated out
  2. filtrationwas filtered off
  3. washwashed with 10 ml of dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-0ee039259ffc44829d7a2b491a05c2bb
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05945534

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