Triethoxysilane → 1H-Pyrrole, 1-(phenylmethyl)-

Temperatur

60 °C

N-benzylsuccinimide (0.38 g, 2.0 mmol), triethoxysilane (1.85 mL, 10 mmol), and titanium (IV) isopropoxide (0.06 mL, 0.2 mmol) were dissolved in C6H6 (4.0 mL) and the mixture was heated to 60 ° C. for 16 hours. The solvent was removed in vacuo and the reaction mixture was poured into a mixture of 1 M NaOH (10 mL) and THF (10 mL). This mixture was stirred for 1 hour, poured into ethyl ether (75 mL), and washed with 1 M NaOH (5×50 mL). The ether layer was dried over MgSO4, filtered, and the solvent was removed in vacuo to produce 0.29 g (91% yield) of N-benzylpyrrole as a yellow oil.

1. customThe solvent was removed in vacuo
2. additionthe reaction mixture was poured into a mixture of 1 M NaOH (10 mL) and THF (10 mL)
3. additionpoured into ethyl ether (75 mL)
4. washwashed with 1 M NaOH (5×50 mL)
5. dry with materialThe ether layer was dried over MgSO4
6. filtrationfiltered
7. customthe solvent was removed in vacuo

ORD-Eintrag

ord-58f0e60f495f45b2ace2c787867927c7

Quelldatensatz

uspto-grants-1993_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05220020