3-Nitro-N-(acetyl)benzenesulfonamide → N-(3-aminophenyl)sulfonylacetamide

HRID 1588039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588039
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([NH:13][C:14](=[O:16])[CH3:15])(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([S:10]([NH:13][C:14](=[O:16])[CH3:15])(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 189578003-Nitro-N-(acetyl)benzenesulfonamide

Produkt 1

HCID 504048N-(3-aminophenyl)sulfonylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Nitro-N-(acetyl)benzenesulfonamide (452 mg) was dissolved in 40 ml of ethanol, treated with 10% palladium/carbon catalyst, and hydrogenated on a Parr apparatus at 30 psi for 15 minutes. The reaction mixture was filtered through Celite and concentrated to give 564 mg of a waxy solid. The title compound was obtained analytically pure after column chromatography on silica gel (chloroform-methanol, 9:1 v/v).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated
  3. customto give 564 mg of a waxy solid

Quellen und Nachweise

ORD-Eintrag
ord-d2785ea9e62d4de7beeaebf5d4e56748
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05220018

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