5-Bromo-6-fluoro-2-methylquinoline → 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

HRID 1589257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589257
[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:13])=[N:7]2.[H][H]>C(O)(=O)C.[Pt]>[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH3:13])[NH:7]2

Komponenten

5

Edukt 2

HCID 130353135-Bromo-6-fluoro-2-methylquinolineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 128968175-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 20 g of 5-bromo-6-fluoroquinaldine in 150 ml of glacial acetic acid was added 2.0 g of platinum on charcoal. The mixture was hydrogenated on a Paar apparatus at a temperature of about 20° C. until the theoretical amount of hydrogen was taken up. The mixture was then filtered through celite to provide a solution of 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine. Evaporation of the solvent provides the desired intermediate. This intermediate could be used directly in Part C below without purification.

Aufarbeitung

  1. filtrationThe mixture was then filtered through celite

Quellen und Nachweise

ORD-Eintrag
ord-e5af20ace377474ba08881a5e0eb9366
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568750

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