4-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one → 2-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

HRID 1589296Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589296
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]([NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][NH:11][C:10](=[O:17])[CH:9]=1)=O>C(O)(=O)C.[Fe]>[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]1[N:14]=[C:13]2[CH2:12][NH:11][C:10](=[O:17])[CH:9]=[C:8]2[N:7]=1

Komponenten

4

Edukt 1

HCID 135209344-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one

Produkt 1

HCID 704558092-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

0.6 g of crude 4-(2-methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one were dissolved in 10 ml of glacial acetic acid, the solution was mixed with two spatula tipsful of iron powder, and the mixture was stirred for 30 minutes at room temperature. The mixture was then refluxed for 20 minutes, filtered, and the filtrate was evaporated in vacuo. The product thus obtained were purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15).

Aufarbeitung

  1. temperatureThe mixture was then refluxed for 20 minutes
  2. filtrationfiltered
  3. customthe filtrate was evaporated in vacuo
  4. customThe product thus obtained
  5. customwere purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15)

Quellen und Nachweise

ORD-Eintrag
ord-18630330845a4e4cb0b76e3da355b2ef
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568680

Notizen zur Reaktion

Wird geladen…