Ammonia → HCID 70455630, Verbindung

HRID 1589297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589297
Cl.C[O:3][C:4]1[C:9]([NH2:10])=[C:8]([NH2:11])[CH:7]=[CH:6][N:5]=1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16](Cl)=O.N>O>[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16]1[N:10]=[C:9]2[C:4](=[O:3])[NH:5][CH2:6][CH:7]=[C:8]2[N:11]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 27595912-Methoxy-4-(methylthio)benzoyl chlorideHCID 202482542-Methoxy-3,4-diamino-pyridine hydrochloride

Produkt 1

HCID 70455630HCID 70455630, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.88 g of 2-methoxy-3,4-diamino-pyridine hydrochloride and 1.08 g of 2-methoxy-4-methylmercapto-benzoyl chloride were intimately mixed, and the mixture was stirred into warm polyphosphoric acid at 120° C. The mixture was kept at this temperature for an hour and was then poured into water, the aqueous mixture was made alkaline with ammonia, and the precipitate thus obtained was purified on a silica gel column (eluant: methylene chloride/methanol=100:10).

Aufarbeitung

  1. waitThe mixture was kept at this temperature for an hour
  2. customthe precipitate thus obtained
  3. customwas purified on a silica gel column (eluant: methylene chloride/methanol=100:10)

Quellen und Nachweise

ORD-Eintrag
ord-8eb90bdb6e014f0b9d71834aa967875a
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568680

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