Hydrochloric Acid → (E,E)-3,7,11,15-tetramethyl-6,10,14-hexadecatrienoic acid

HRID 1589529Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589529
[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:21])/[CH2:10][CH2:11]/[CH:12]=[C:13](\[CH3:20])/[CH2:14][CH2:15][CH:16]=[C:17]([CH3:19])[CH3:18])[CH2:3][C:4]#N.[OH-:22].[K+].C(O)C([OH:27])C.Cl>O>[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:21])/[CH2:10][CH2:11]/[CH:12]=[C:13](\[CH3:20])/[CH2:14][CH2:15][CH:16]=[C:17]([CH3:19])[CH3:18])[CH2:3][C:4]([OH:27])=[O:22]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 1030Propylene GlycolHCID 14797Potassium HydroxideHCID 11414994(E, E)-3,7,11,15-Tetramethyl-6,10,14-hexadecatrienonitrile

Produkt 1

HCID 12837064(E,E)-3,7,11,15-tetramethyl-6,10,14-hexadecatrienoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 34 g. of the product obtained in the above (b) step, there were added 23 g. of potassium hydroxide, 10 ml. of water and 70 ml. of propylene glycol, and the mixture was stirred at 130° C. for 7 hours. The reaction mixture was made acidic by addition of hydrochloric acid, and was then extracted with n-hexane. The extract was washed with water and dried, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography to obtain 30 g. of the desired oily product.

Aufarbeitung

  1. additionwere added 23 g
  2. extractionwas then extracted with n-hexane
  3. washThe extract was washed with water
  4. customdried
  5. customthe solvent was removed by evaporation
  6. customThe residue was purified by silica gel column chromatography
  7. customto obtain 30 g

Quellen und Nachweise

ORD-Eintrag
ord-16a9874dacc94f7abafe448a033eca89
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04571408

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