Reaktionsgleichung
[CH:1]12[CH2:8][CH2:7][CH:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:9]1[N:18]=[C:17]2[C:12]([C:13](=[O:24])[C:14]([C:21]([OH:23])=[O:22])=[CH:15][N:16]2[CH2:19][CH3:20])=[CH:11][C:10]=1[F:25].[CH2:26]([I:28])[CH3:27].C(N(CC)CC)C>CN(C)C=O>[IH:28].[CH2:19]([N:16]1[C:17]2[C:12](=[CH:11][C:10]([F:25])=[C:9]([N:2]3[CH2:3][CH:4]4[CH2:7][CH2:8][CH:1]3[CH2:6][N:5]4[CH2:26][CH3:27])[N:18]=2)[C:13](=[O:24])[C:14]([C:21]([OH:23])=[O:22])=[CH:15]1)[CH3:20]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 0.35 g (1.0 mmole) of 7-(2,5-diazabicyclo[2.2.2]oct-2-yl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, 0.32 ml (4.0 mmole) of ethyl iodide, 0.56 ml (4.0 mmole) triethylamine and 10 ml of N, N-dimethylformamide was heated at 100° for 17 hours. The reaction mixture was evaporated to dryness and the residue was stirred with 25 ml of 1 N sodium hydroxide for one hour. The solution was neutralized to pH 7 with 1 N hydrochloric acid, filtered and evaporated the filtrate to dryness. The residue was recrystallized from ethanol to give 0.29 g of the title compound, mp>300°.
Aufarbeitung
- customThe reaction mixture was evaporated to dryness
- filtrationfiltered
- customevaporated the filtrate to dryness
- customThe residue was recrystallized from ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-dee1b1e77f69402284755a2f421b158e
- Quelldatensatz
- uspto-grants-1986_02
- Patentnummer
- US04571396
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