3,6-Dichloro-2-nitrophenol → 2-amino-3,6-dichloroPhenol

HRID 1589787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589787
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12]>C(O)C.C(O)(=O)C.[Pt]>[NH2:9][C:4]1[C:5]([Cl:8])=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[OH:12]

Komponenten

5

Edukt 1

HCID 30141723,6-Dichloro-2-nitrophenol

Produkt 1

HCID 103973432-amino-3,6-dichloroPhenolAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23939PlatinumKatalysatorHCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A yellow solution of 2,5-dichloro-6-nitrophenol (10.0 g, 48.0 mmol) in ethanol (200 mL) and acetic acid (13.8 mL) at 0° C. was catalytically reduced in the presence of 5% platinum on charcoal (0.15 g) under an atmosphere of hydrogen (25 psi) for 1 hour in a Parr hydrogenator. The resultant colorless solution was filtered and concentrated under reduced pressure (15 torr). The residue was then dried under high vacuum (0.02 torr) overnight to yield 8.52 g (100%) of 2-amino-3,6-dichlorophenol.

Aufarbeitung

  1. filtrationThe resultant colorless solution was filtered
  2. concentrationconcentrated under reduced pressure (15 torr)
  3. customThe residue was then dried under high vacuum (0.02 torr) overnight

Quellen und Nachweise

ORD-Eintrag
ord-d8f3e34204a74b1983af7ceab47b6c28
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05200329

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