Sodium Bicarbonate → Dimiracetam

HRID 1589818

Reaktionsgleichung

Reaktionsgleichung von HRID 1589818
Cl.[O:2]=[C:3]1[NH:7][CH:6]([CH2:8][CH2:9][C:10]([O:12]CC(C)C)=O)[NH:5][CH2:4]1.C(=O)([O-])O.[Na+]>O>[O:2]=[C:3]1[CH2:4][N:5]2[C:10](=[O:12])[CH2:9][CH2:8][CH:6]2[NH:7]1

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 67886019Isobutyl 5-oxo-2-imidazolidinepropanoate hydrochloride

Produkt 1

HCID 65955DimiracetamAusbeute 37,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A solution of isobutyl 5-oxo-2-imidazolidinepropanoate hydrochloride (1.4 g, 5.76 mmol) in water (100 ml) was treated with sodium hydrogen carbonate (0.54 g, 6.4 mmol) and heated at 100° C. for 20 hours. The solution was evaporated and the residue was chromatographed over silica gel (ethyl acetate-acetone-methanol 6:3:1) to afford 300 mg (37%) of the title compound, m.p. 155°-157° C.

Aufarbeitung

  1. customThe solution was evaporated
  2. customthe residue was chromatographed over silica gel (ethyl acetate-acetone-methanol 6:3:1)

Quellen und Nachweise

ORD-Eintrag
ord-fbef470ddca244dcbc1fd3c5aee9b227
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05200406

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