Diethyl Ether → HCID 57153373, Verbindung

HRID 1590265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1590265
[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=O)[C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH:16]1[CH2:20][O:21][CH3:22].CCOCC>C1C=CC=CC=1>[CH3:22][O:21][CH2:20][CH:16]1[CH2:17][CH2:18][CH2:19][N:15]1[N:14]=[C:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]1=[O:13]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 1436632-(Methoxymethyl)pyrrolidin-1-amineHCID 190235711-Phenylpyrrolidine-2,3-dione

Produkt 1

HCID 57153373HCID 57153373, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A solution of the product of Example 61 and chiral 1-amino-2-methoxymethylpyrrolidine (SAMP or RAMP; 1 equiv) in benzene is refluxed under Dean-Stark conditions for 20 h After cooling, Et2O is added and the mixture is washed with water. The organic layer is dried (MgO4), and evaporated to give a residue which is chromatographed on silica gel to give the title compound.

Aufarbeitung

  1. temperatureAfter cooling
  2. washthe mixture is washed with water
  3. customThe organic layer is dried (MgO4)
  4. customevaporated
  5. customto give a residue which
  6. customis chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-4025d25706be4a47bd53045e959c41ba
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05202344

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