Hydrochloric Acid → 3-Ethylisoxazole-5-carboxanilide

HRID 1590993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1590993
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([C:10]1[CH:14]=[C:13]([C:15](Cl)=[O:16])[O:12][N:11]=1)[CH3:9].O.Cl>ClCCl>[CH2:8]([C:10]1[CH:14]=[C:13]([C:15]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:16])[O:12][N:11]=1)[CH3:9]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6115AnilineHCID 129051013-Ethylisoxazole-5-carbonyl chloride

Produkt 1

HCID 156929113-Ethylisoxazole-5-carboxanilideAusbeute 87,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

11.7 g of aniline are added dropwise to 10.0 g of 3-ethylisoxazole-5-carbonyl chloride in 150 ml of dichloromethane, while cooling with ice. The mixture is stirred overnight at room temperature, water and concentrated hydrochloric acid are added and the organic phase is separated off, washed with sodium bicarbonate solution and evaporated down to give 11.8 g of 3-ethylisoxazole-5-carboxanilide as colorless crystals of melting point 122°-124° C.

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. customthe organic phase is separated off
  3. washwashed with sodium bicarbonate solution
  4. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-ad954ba27e094bbe9e91c6b0a3497897
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05205854

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