4-Methyl-3-nitrobenzotrifluoride → 2-Methyl-5-(trifluoromethyl)aniline

HRID 1591097

Reaktionsgleichung

Reaktionsgleichung von HRID 1591097
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-])=O>C(O)C.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[NH2:12]

Komponenten

4

Edukt 1

HCID 14728854-Methyl-3-nitrobenzotrifluoride

Produkt 1

HCID 27359332-Methyl-5-(trifluoromethyl)anilineAusbeute 79,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Methyl-5-trifluoromethylnitrobenzene (14.8 g) was dissolved in ethanol (100 ml) and hydrogenated at ambient temperature and pressure in the presence of palladium on charcoal (10%; 0.5 g). The solution was filtered and evaporated to dryness to give 2-methyl-5-trifluoromethylaniline (10.1 g) as a pale yellow oil.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-b60f6c0e4e074d2484a1a5236d4de3b2
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05206257

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