1-(3-Azidopropyl)-4-fluorobenzene → 3-(4-Fluorophenyl)propan-1-amine

HRID 1592321

Reaktionsgleichung

Reaktionsgleichung von HRID 1592321
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]=[N+]=[N-])=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][NH2:11])=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 589977011-(3-Azidopropyl)-4-fluorobenzene

Produkt 1

HCID 64837963-(4-Fluorophenyl)propan-1-amineAusbeute 57,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The product from step e (0.79 g, 6.4 mmol) was dissolved in 100 mL of MeOH and added carefully to 0.20 g of 10% Pd/C under N2. The mixture was hydrogenated in a Parr shaker at 50 PSI overnight. Filtration through fiberglass filter paper under N2 and under vacuum yielded 0.56 g of a clear colorless oil.

Aufarbeitung

  1. customwas hydrogenated in a Parr shaker at 50 PSI overnight
  2. filtrationFiltration through fiberglass
  3. filtrationfilter paper under N2

Quellen und Nachweise

ORD-Eintrag
ord-e98aa9fc6dbc41d6b7b745af3d109ccc
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07291744B2

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