Aluminium lithium hydride → 3-(4-Fluorophenyl)propanal

HRID 1592350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1592350
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH:10]=[O:11])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 22612404N-Methoxy-N-methyl-4-fluoro-benzenepropanamide

Produkt 1

HCID 101977823-(4-Fluorophenyl)propanal

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The crude amide was dissolved in ether and cooled in an ice bath and treated with LAH (1.35 g, 35 mmol) and stirred for 1 hour. The reaction was quenched with 1 N HCl, extracted with ethyl acetate and washed successively with water and brine, dried over MgSO4. The extract was filtered and evaporated under vacuum to give 4.3 g of 3-(4-fluorophenyl)propanal.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customThe reaction was quenched with 1 N HCl
  3. extractionextracted with ethyl acetate
  4. washwashed successively with water and brine
  5. dry with materialdried over MgSO4
  6. filtrationThe extract was filtered
  7. customevaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8fc62ebd43a44bc299c210eec26b1a11
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07291744B2

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