Hydrochloric Acid → 2-Cyclopropylquinazoline-6-carboxylic acid
Reaktionsgleichung
C[CH:2]([OH:4])[CH3:3].[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=C(C#N)[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1.[OH-:20].[K+].Cl>O>[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([OH:4])=[O:20])[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Into 8 ml of 2-propanol and 1 ml of water were dissolved 210 mg of 2-cyclopropylquinazoline-6-carbonitrile and 450 mg of potassium hydroxide, followed by heating under refluxing overnight. Hydrochloric acid was added thereto and the solvent was removed by evaporation to obtain the title compound as a crude carboxylic acid.
Aufarbeitung
- temperatureby heating
- temperatureunder refluxing overnight
- customthe solvent was removed by evaporation
Quellen und Nachweise
- ORD-Eintrag
- ord-bc5bbe1747a94d5eb61ba7ee5ccd0dc9
- Quelldatensatz
- uspto-grants-2007_11
- Patentnummer
- US07297698B2
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